The article is devoted to the analysis of the influence of the ideology of transhumanism on gender self-identification. The values of transhumanism are very successfully institutionalized in modern, especially Western, society, and this process is fraught with serious threats to human being. In the process of analyzing this phenomenon, the author comes to the conclusion that the result of such institutionalization often becomes gender dysphoria, when a person can not fully accept his gender status of a man or a woman.