The article is devoted to the actualization of the principle of uniqueness for methodology in philosophy and epistemology. This is due to the fact that no attention is paid to the uniqueness in scientific discourse. However, if general and universal could be the necessary results of cognition for the natural science, then for humanities the heuristic status of uniqueness should become the aim of research at least due to the fact of the uniqueness of a human being and personality in the context of anthropology.
